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The Nrf2KEAP1 pathway stands as a master regulator of this balance, transcriptionally activating genes involved in GSH biosynthesis (GCLC, GCLM, GSR, and GSS), iron metabolism (FTL, FTH1, FPN1, and HO-1), and redox defense (SLC7A11, GPX4, and NQO1)all of which directly modulate ferroptosis susceptibility (283, 284)

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These findings show that, despite targeting similar receptors, psilocybin and lisuride diverge in their neurobiological pathways and behavioral outcomes, shedding light on the mechanisms distinguishing psychedelics from non-psychedelics

Many patients report feeling better even before the session ends

Neural circuits of interoception